Structural Genomics at BNL
Structural genomics is the systematic determination of 3-dimensional
structures of proteins representative of the range of protein structure and
function found in nature. The aim, ultimately, is to build a body of
structural information that will facilitate prediction of a reasonable
structure and potential function for almost any protein from knowledge
of its coding sequence. Such information will be essential for understanding
the functioning of the human proteome, the ensemble of tens of thousands of
proteins specified by the human genome.
BNL is a member of the New York Structural Genomics Research Consortium
(NYSGRC), which is supported by the Protein Structure
Initiative of the National Institute of General Medical Sciences (NIGMS) to be a
Pilot Structural Genomics Center. Procedures are being developed for high-throughput
x-ray crystallography of proteins expressed from cloned genomic or cDNA.
Initial targets include a variety of yeast proteins, proteins associated with human
disease, and proteins of human pathogens. Protein targets and progress toward
structure determination will be posted on the NYSGRC web site.
BNL is independently taking a structural genomics approach to gain structural
information about human proteins that are involved in sensing and repairing
DNA damage. This work is supported by the Office of Biological and Environmental
Research of the Department of Energy. Protein targets and progress toward structure
determination will be posted on this site in the following tables:
Proteins Selected for Expression and Structure Determination
Progress Toward Structure Solution by X-ray Crystallography
Participants in BNL Structural Genomics Efforts
Cloning, Expression and Purification
F. William Studier
Helen Kycia
Nancy Manning
Eileen Matz
Structure Determination by X-ray Crystallography
S. Swaminathan
S. Eswaramoorthy
D. Kumaran
Maria Bewley
John Flanagan
Jiansheng Jiang